ActiveDriverWGS

Driver discovery in coding and non-coding regions of cancer genomes.

ActiveDriverWGS uses Poisson regression to find genes and non-coding elements with more mutations than expected from the adjacent sequence, adjusting for trinucleotide context.

Please cite

Candidate cancer driver mutations in distal regulatory elements and long-range chromatin interaction networks
Helen Zhu^*, Liis Uusküla-Reimand^*, Keren Isaev^*, Lina Wadi, Azad Alizada, Shimin Shuai, Vincent Huang, Dike Aduluso-Nwaobasi, Marta Paczkowska, Diala Abd-Rabbo, Oliver Ocsenas, …, J Drew Thompson, Yao Li, Luyao Ruan, Michal Krassowski, Irakli Dzneladze, …, Michael D Wilson, Jüri Reimand

Molecular Cell 2020 doi code