ActiveDriverDB

Database of human genetic variation at protein modification sites.

Archived The web server was retired in May 2026; code and data remain on GitHub.

ActiveDriverDB annotates missense variants at post-translational modification sites, including cancer mutations, inherited disease mutations and population variants, and predicts how they rewire kinase signalling networks.

Please cite

ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins
Michal Krassowski, Marta Paczkowska, Kim Cullion, Tina Huang, Irakli Dzneladze, BF Francis Ouellette, Joseph T Yamada, Amelie Fradet-Turcotte, Jüri Reimand

Nucleic Acids Research 2018 doi