two PCAWG preprints on non-coding driver mutations

99% of the genome is non-coding, yet we know hundreds of cancer genes with protein-coding driver mutations and only a few non-coding driver mutations. As the international collaboration project ICGC-TCGA PCAWG is nearing completion, two preprints were uploaded to bioRxiv in the last week of December 2017.

The preprint of the PCAWG drivers paper describes known and candidate driver mutations in regions near genes across 2,500 whole cancer genomes (

A satellite manuscript led by our lab describes driver mutations in distal gene regulatory elements such as super-enhancers and regions involved in long-range chromatin interactions (