We are currently evaluating applications for the research assistant position advertised recently. and will contact top-ranking candidates in the near future. New positions will be opening shortly.
We seek a talented and highly motivated Bioinformatician to contribute to the development of a world-class bioinformatics platform in cancer genomics. Application deadline is Aug 2nd 2016.
Position: Research assistant, bioinformatics & cancer research
Site: MaRS Centre
Department: Informatics & Biocomputing
Reports To: Principal Investigator (Dr. J. Reimand)
Salary: Commensurate with level of experience
Hours: 35 Hrs/week
Status: Full-time, Permanent
About us: The OICR is a top-ranking translational cancer research institute located in the Discovery District of downtown Toronto, one of the top three biotechnology hubs in North America and an exceptionally collaborative environment. As part of international cancer research teams, the ICGC (International Cancer Genome Consortium) and TCGA (The Cancer Genome Atlas), we have early access to large and diverse cancer datasets that will become the standard reference set for cancer genomics studies in the coming years. These datasets provide exciting challenges for interpretation, and many opportunities to make new discoveries and to develop innovative computational tools. In particular, we are leading several aspects of the ICGC Pan-Cancer Analysis Working Group (PCAWG), a collaboration of hundreds of experts to analyse whole-genome sequencing (WGS) data across more than 2,800 donors and 50 types of cancer. The recently launched next-generation project ICGCmed will advance precision treatment strategies by linking cancer genomes of >200,000 individuals to high-quality clinical information. Our analyses are performed on cutting-edge IT infrastructure including a multi-petabyte storage system and a >8,000-core compute farm.
About the position: We seek a talented and highly motivated Bioinformatician to contribute to the development of a world-class bioinformatics platform in cancer genomics. The research questions you will be addressing include: Which genome mutations are important in cancer development and how do they function mechanistically? How are biological pathways and molecular interaction networks altered by mutations, gene regulation, epigenetic modifications and DNA rearrangements? Which genes are promising targets for future drugs, and how can we repurpose existing drugs to treat cancer? How do we build computational models, bioinformatics software and novel visualisations to integrate complex multi-dimensional datasets and discover new knowledge?
- As a successful candidate, you will have extensive interest in large-data problems, excellent quantitative analysis skills and in-depth knowledge of cancer genomics. You will analyse diverse -omics datasets to explore the basic biology of cancer and to drive discovery of molecular biomarkers and personalised therapies. You will work closely with the team and the Principal Investigator on cancer genomics projects in collaborations with basic, translational, and clinical researchers at the OICR, in the excellent research community of Toronto and internationally. Your tasks will include:
- Integrative analysis of multi-dimensional cancer genomics datasets using statistical and machine learning approaches;
- Pre-processing, normalization, and quality control of next-generation sequencing (WGS) and other –omics data;
- Development of innovative computational methods and open-source bioinformatics software;
- Visualization and interpretation of –omics data with pathway and network information.
- University degree in bioinformatics, computational biology or computer sciences with significant bioinformatics experience. A graduate degree (MSc or PhD) is a strong asset;
- Minimum of 1 year of professional experience in bioinformatics; • Solid knowledge of statistical programming (GNU R preferred) and scripting languages (Python, Perl);
- Familiarity with the Linux or MacOSX environment, shell scripting and system tools; experience with high performance computing is an asset;
- Strong knowledge of basic statistics; machine learning skills are a definite plus;
- Experience with data visualisation and graphic design;
- Experience with bioinformatics resources, databases, tools and common standard formats;
- Strong knowledge of and interest in molecular biology, genomics, and cancer;
- Experience in analysing next-generation sequencing and/or microarray data;
- Ability to work independently as well as part of a fast-paced and collaborative team;
- Excellent verbal and written communication skills in English.
OICR is an innovative cancer research institute located in the MaRS Centre in the Discovery District in downtown Toronto. OICR is addressing significant challenges in cancer research with multi-disciplinary, multi-institutional teams. New discoveries to prevent, detect and treat cancer will be moved from the bench to practical applications in patients. The OICR team is growing quickly. We are innovative, dedicated professionals who bring expertise to each of our roles. We are looking for individuals interested in being part of a culture of excellence that will result in Ontario being recognized internationally as a leading jurisdiction for cancer research.
Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Research and Innovation. For more information about OICR, please visit the website at www.oicr.on.ca.
POSTED DATE: July 13, 2016
CLOSING DATE: August 2, 2016
OICR has a diverse workforce and is an equal opportunity employer.
The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted. Candidates will be expected to provide their current employer as a reference.